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| Pasin,J.S.M.; Ferreira,A.P.O.; Saraiva,A.L.L.; Ratzlaff,V.; Andrighetto,R.; Machado,P.; Marchesan,S.; Zanette,R.A.; Bonacorso,H.G.; Zanatta,N.; Martins,M.A.P.; Ferreira,J.; Mello,C.F.. |
| The objective of this study was to determine the effect of eight 5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1-carboxyamidepyrazoles (TFDPs) on rat body temperature and baker’s yeast-induced fever. TFDPs or vehicle (5% Tween 80 in 0.9% NaCl, 5 mL/kg) were injected subcutaneously and rectal temperature was measured as a function of time in 28-day-old male Wistar rats (N = 5-12 per group). Antipyretic activity was determined in feverish animals injected with baker’s yeast (Saccharomyces cerevisiae suspension, 0.135 mg/kg, 10 mL/kg, ip). 3-Ethyl- and 3-propyl-TFDP (140 and 200 μmol/kg, respectively, 4 h after yeast injection) attenuated baker’s yeast-induced fever by 61 and 82%, respectively. These two effective antipyretics were selected for subsequent... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pyrazole derivatives; Fever; Cytokine levels; Cyclooxygenase. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001200009 |
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| Berezin,Eitan Naaman; Iazzetti,Marco Antonio. |
| We reviewed the incidence of occult bacteremia, to identify the most frequent etiological agents of bacteremias in otherwise healthy children from one month to 10 years old, who had fever of unknown origin attended at the emergency ward of an urban, university-affiliated pediatric referral center. This was a retrospective medical record review, evaluating children with fever. Data were collected from the initial visit, when blood cultures, hematological properties and hemosedimentation rates were examined. Fever was considered as the highest temperature assessed in the hospital or reported by the responsible adult. Occult bacteremia was discovered in 1.4% of the 1,051 children evaluated, and the most common etiologic agent was Streptococcus pneumoniae.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fever; Streptococcus pneumoniae; Occult bacteremia. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600007 |
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| Petrilli,Antonio Sérgio; Cypriano,Monica; Dantas,Lenice Silva; Lee,Lúcia Martino; Luisi,Maria Flávio Augusto Vercillo; Silva,Katia Veronica Torres B.; Pereira,Carlos Alberto Pires. |
| BACKGROUND: The empirical use of antibiotic treatments is widely accepted as a means to treat cancer patients in chemotherapy who have fever and neutropenia. Intravenous monotherapy, with broad spectrum antibiotics, of patients with a high risk of complications is a possible alternative. METHODS: We conducted a prospective open-label, randomized study of patients with lymphoma or leukemia who had fever and neutropenia during chemotherapy. Patients received either monotherapy with ticarcillin/clavulanic acid (T) or ceftriaxone plus amikacin (C+A). RESULTS: Seventy patients who presented 136 episodes were evaluated, 68 in each arm of the study. The mean neutrophil counts at admission were 217cells/mm³ (T) and 201cells/mm³ (C+A). The mean duration of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fever; Neutropenia; Leukemia; Lymphoma; Ticarcillin; Ceftriaxone. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200003 |
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| 古村, 圭子; 塚本, 夢乃. |
| 子牛は下痢や肺炎などに罹患しやすい。子牛の体調の不具合を早期に発見し、不具合の要因を知り解決することが、子牛を健康に飼育するために重要である。測定項目数が多く器具を使用する従来のカウシグナル（CS）と比較して、測定器具を使わず、簡単で瞬時に判定可能な新たなカウシグナル（NCS）を見つけることが有益である。そしてその方法は子牛の飼養管理の省力化と疾病の早期発見に繋がる。 本実験は2014 年７月末から10 月初旬にかけて出生した雌子牛から、離乳後の６頭を供試した。スコアリングは2014 年11 月から2015 年３月まで行った。新たなカウシグナル（NCS）は、顔に集中する３項目（鼻鏡の乾き、白目の色の変化、下まぶたのくぼみ）のスコア値を各々定義して、スコア表を設計した。従来のカウシグナルのスコア表とNCS スコア表による健康評価を、120 回（20 回／頭）行い、両スコアによる評価の一致率を分析した。NCS の発生要因を検討するため、5つの症状（脱水、発熱、下痢、咳、鼻水）もスコアリング時に測定した。これらの症状とNCS との関係性を、Excel 分析ツール（2013）およびSAS（ver9.4）で分析した。 子牛の体全体を評価するCS と、顔の部位のみの観察で評価するNCS とを比較して、両者の健康評価の一致率は82.5％であった（Kappa 係数＝ 0.48）。NCS の３項目は、発熱症状と関係性が強く、特に鼻鏡の乾きとの間に、最も高いクラメール連関係数が得られた（V=0.48）。発熱群（直腸温度≧ 39.3℃）と非発熱群（直腸温度≦ 39.2℃）において、鼻鏡の粘液の分泌量には有意な差がみられた（P ≦... |
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Palavras-chave: New calf signal (NCS); Calf screening; Dryness of the muzzle; Fever; Rectal temperature. |
| Ano: 2017 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4556 |
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| Licinio,J.; Frost,P.. |
| Cytokines are molecules that were initially discovered in the immune system as mediators of communication between various types of immune cells. However, it soon became evident that cytokines exert profound effects on key functions of the central nervous system, such as food intake, fever, neuroendocrine regulation, long-term potentiation, and behavior. In the 80's and 90's our group and others discovered that the genes encoding various cytokines and their receptors are expressed in vascular, glial, and neuronal structures of the adult brain. Most cytokines act through cell surface receptors that have one transmembrane domain and which transduce a signal through the JAK/STAT pathway. Of particular physiological and pathophysiological relevance is the fact... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Central nervous system; Cytokines; Immune system; Neuroendocrine regulation; Fever; Food intake. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001000003 |
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